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Project Number: | I01BX004049-01 |
| Title: | Interferon Beta Initiated Development of Immunogenic T1 B cells in Lupus |
| Principal Investigator: | John D. Mountz |
| Location: | Birmingham, AL |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2017 - September 2021 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$769,986 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Systemic lupus erythematosus (SLE) is a chronic debilitating disease that is characterized by high titers of autoantibodies with specificity for nuclear autoantigens. It is considered to arise from interactions between underlying genetic susceptibility and environmental factors, with different combinations resulting in inter- individual variations in disease manifestations and therapeutic responsiveness. Directed therapeutic targeting of specific pathways has not proven effective, which suggests... |