Funded Project Details - FY2021
|Title:|| Mechanisms of pharmacological ascorbate inhibition of pancreatic cancer metastases|
Joseph J. Cullen
||Iowa City, IA
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2018 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Metastases are a major cause of pancreatic ductal adenocarcinoma (PDAC) mortality, accounting for as many as 90% of cancer-related deaths. Therapies specifically designed to inhibit the mechanisms of invasion that drive metastases are not currently utilized as part of PDAC treatment. We propose that targeting invasion and metastases by exploiting fundamental differences in cancer cell oxidative metabolism using pharmacological ascorbate (P-AscH−) can enhance therapy outcomes in PDAC. Our studies...
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