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Funded Project Details - FY2021

Project Number:

Title: Mechanisms of pharmacological ascorbate inhibition of pancreatic cancer metastases
Principal Investigator:

Joseph J. Cullen

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Metastases are a major cause of pancreatic ductal adenocarcinoma (PDAC) mortality, accounting for as many as 90% of cancer-related deaths. Therapies specifically designed to inhibit the mechanisms of invasion that drive metastases are not currently utilized as part of PDAC treatment. We propose that targeting invasion and metastases by exploiting fundamental differences in cancer cell oxidative metabolism using pharmacological ascorbate (P-AscH−) can enhance therapy outcomes in PDAC. Our studies...

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