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Funded Project Details - FY2021




Project Number:

I01BX002559-05
Title: Interactions between inflammatory and oncogenic signaling pathways in GBM
Principal Investigator:

Amyn Habib

Location: Dallas, TX
Congressional District Code: 30
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $180,350
Total Award Amount
(all years):
$1,000,550
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

  Inhibition of epidermal growth factor receptor (EGFR) signaling is an important approach to the targeted treatment of cancer. However, although aberrant EGFR signaling is widespread in cancer, EGFR inhibition is primarily effective only in a limited number of lung cancers that express specific EGFR mutations and are oncogene addicted. Thus, the ability to render cancer cells with primary EGFR resistance sensitive to EGFR inhibition is potentially of enormous clinical value, given the wide prev...



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