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Project Number: | I01BX003772-01A2 |
| Title: | Cellular Sources of Self Antigen in SLE |
| Principal Investigator: | David S. Pisetsky |
| Location: | Durham, NC |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2022 |
| FY 2023 Funding Amount: | $0 |
| Total Award Amount (all years): |
$728,750 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Abstract Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with severe multisystem inflammatory disease manifestations. ANAs target a wide array of nuclear macromolecules and can mediate disease by the formation of immune complexes that deposit in the tissue to promote inflammation and damage; these complexes can also stimulate the production of cytokines including type 1 interferon to drive gener... |