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Funded Project Details - FY2023

Project Number:

Title: Cellular Sources of Self Antigen in SLE
Principal Investigator:

David S. Pisetsky

Location: Durham, NC
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2022
FY 2023 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with severe multisystem inflammatory disease manifestations. ANAs target a wide array of nuclear macromolecules and can mediate disease by the formation of immune complexes that deposit in the tissue to promote inflammation and damage; these complexes can also stimulate the production of cytokines including type 1 interferon to drive gener...

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