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Funded Project Details - FY2021




Project Number:

I01BX003772-01A2
Title: Cellular Sources of Self Antigen in SLE
Principal Investigator:

David S. Pisetsky

Location: Durham, NC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$698,750
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Abstract Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with severe multisystem inflammatory disease manifestations. ANAs target a wide array of nuclear macromolecules and can mediate disease by the formation of immune complexes that deposit in the tissue to promote inflammation and damage; these complexes can also stimulate the production of cytokines including type 1 interferon to drive gener...



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