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Funded Project Details - FY2021

Project Number:

Title: Dendritic Cell Proteoglycans and Reprogramming Cancer Immunity
Principal Investigator:

Mark M. Fuster

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Early in cancer growth, metastases and dendritic cells (DCs) traffic to draining lymph nodes (DLN). In lung cancer and other carcinomas, immune-suppression dominates a tumor microenvironment characterized by immature DCs, weak T-effector responses, proliferation of T-regulatory cells (Tregs), and over-production of immuno-suppressive cytokines. This heavily represses anti-tumor immunity. A high-impact area of new scientific discovery is immunotherapy. We find dramatic clinical responses in some...

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