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Funded Project Details - FY2021




Project Number:

I01BX002137-05A1
Title: NOVEL MECHANISMS AND THERAPEUTIC APPROACHES TO IMMUNO-INFLAMMATORY LONG OT SYNDROME
Principal Investigator:

Mohamed Boutjdir

Location: Brooklyn, NY
Congressional District Code: 11
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$945,066
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Recent evidence show that patient with autoimmune and inflammatory disorders have high circulating levels of both anti-Ro antibodies (Abs) and interleukin 6 (IL-6) both of which are associated with prolongation of corrected QT interval (QTc) on ECG. In this renewal application, we will test the overall hypothesis that anti-Ro Abs and IL-6 will inhibit the delayed rectifier HERG-K channel thus accounting for the clinical QTc prolongation and predisposition to cardiac arrhythmias. During the last...



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