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Project Number: | I01BX001584-05A2 |
| Title: | Molecular Manipulation to Enhance Anti-Myeloma Response |
| Principal Investigator: | Nikhil C. Munshi |
| Location: | Brockton, MA |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2021 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$773,307 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Genomic adaptability of the tumor cells is the major obstacle in achieving successful cancer treatment. We have studied both tumor cells and their microenvironment in multiple myeloma (MM), a plasma cell malignancy. The immune microenvironment in MM exhibit considerable dysfunction1. In our previous work, we showed that dysfunctional regulatory T helper cells (Tregs)2, iNKT cells3, and elevated Th17 cells and IL-17A, increase MM cell growth and survival and suppress immune responses and induce b... |