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Funded Project Details - FY2021




Project Number:

I01BX001584-05A2
Title: Molecular Manipulation to Enhance Anti-Myeloma Response
Principal Investigator:

Nikhil C. Munshi

Location: Brockton, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$773,307
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Genomic adaptability of the tumor cells is the major obstacle in achieving successful cancer treatment. We have studied both tumor cells and their microenvironment in multiple myeloma (MM), a plasma cell malignancy. The immune microenvironment in MM exhibit considerable dysfunction1. In our previous work, we showed that dysfunctional regulatory T helper cells (Tregs)2, iNKT cells3, and elevated Th17 cells and IL-17A, increase MM cell growth and survival and suppress immune responses and induce b...



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