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Funded Project Details - FY2021

Project Number:

Title: Molecular Manipulation to Enhance Anti-Myeloma Response
Principal Investigator:

Nikhil C. Munshi

Location: Brockton, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Genomic adaptability of the tumor cells is the major obstacle in achieving successful cancer treatment. We have studied both tumor cells and their microenvironment in multiple myeloma (MM), a plasma cell malignancy. The immune microenvironment in MM exhibit considerable dysfunction1. In our previous work, we showed that dysfunctional regulatory T helper cells (Tregs)2, iNKT cells3, and elevated Th17 cells and IL-17A, increase MM cell growth and survival and suppress immune responses and induce b...

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