Office of Research & Development |
![]() ![]() |
Project Number: | I01BX001584-05A2 |
Title: | Molecular Manipulation to Enhance Anti-Myeloma Response |
Principal Investigator: | Nikhil C. Munshi |
Location: | Brockton, MA |
Congressional District Code: | 7 |
Research Service: | Biomedical Laboratory R&D |
Project Period: | January 2018 - December 2021 |
FY 2021 Funding Amount: | $156,800 |
Total Award Amount (all years): |
$773,307 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Genomic adaptability of the tumor cells is the major obstacle in achieving successful cancer treatment. We have studied both tumor cells and their microenvironment in multiple myeloma (MM), a plasma cell malignancy. The immune microenvironment in MM exhibit considerable dysfunction1. In our previous work, we showed that dysfunctional regulatory T helper cells (Tregs)2, iNKT cells3, and elevated Th17 cells and IL-17A, increase MM cell growth and survival and suppress immune responses and induce b... |