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Funded Project Details - FY2021

Project Number:

Title: Autocrine/Paracrine Regulation of Intrahepatic Bile Duct Growth
Principal Investigator:

Gianfranco D. Alpini

Location: Indianapolis, IN
Congressional District Code: 31
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Nonalcoholic fatty liver disease (NAFLD) is an alarming public health concern and now considered the most common liver disease in the Western world. Patients with NAFLD may develop nonalcoholic steatohepatitis (NASH) of which many develop hepatic injury that may progress to cirrhosis. We have previously shown that in chronic cholestatic liver diseases, cholangiocytes, through the products of their cellular activation such as secretin (SCT), are the key link between bile duct injury and the subep...

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