Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX002452-05
Title: Kinetic Barriers of Transdifferentiation
Principal Investigator:

Jian Feng

Location: Buffalo, NY
Congressional District Code: 26
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $207,516
Total Award Amount
(all years):
$1,025,564
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Abstract Dysfunction of the serotonergic system is critically involved in a diverse range of diseases, which accumulatively affect at least 20% of the population. In our preliminary studies, we identified transcription factors that converted human fibroblasts to induced serotonergic (i5HT) neurons. The efficiency was significantly increased by p53 knockdown and appropriate cell culture conditions. At day 12 of reprogramming, 50% of the cells were Tuj1+ neurons and 25% were 5HT+ neurons. This ep...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.