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Project Number: | I01BX002452-05 |
| Title: | Kinetic Barriers of Transdifferentiation |
| Principal Investigator: | Jian Feng |
| Location: | Buffalo, NY |
| Congressional District Code: | 26 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2022 |
| FY 2021 Funding Amount: | $207,516 |
| Total Award Amount (all years): |
$1,025,564 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Abstract Dysfunction of the serotonergic system is critically involved in a diverse range of diseases, which accumulatively affect at least 20% of the population. In our preliminary studies, we identified transcription factors that converted human fibroblasts to induced serotonergic (i5HT) neurons. The efficiency was significantly increased by p53 knockdown and appropriate cell culture conditions. At day 12 of reprogramming, 50% of the cells were Tuj1+ neurons and 25% were 5HT+ neurons. This ep... |