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Project Number: | I01BX001793-05A1 |
| Title: | Mechanisms of action: the effects of lipoic acid on macrophages,endothelial cells and CNS function in MS |
| Principal Investigator: | Sonemany Salinthone |
| Location: | Portland, OR |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2017 - September 2021 |
| FY 2021 Funding Amount: | $319,221 |
| Total Award Amount (all years): |
$1,477,992 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Multiple sclerosis (MS) is an often disabling disease of the central nervous system (CNS) that affects more than 2.5 million people worldwide. Current FDA approved disease modifying therapies for MS are only partially effective, are costly and have side effects. Thus, there is a need for the continued development of new treatment strategies and targets for successful management of MS. The antioxidant lipoic acid (LA) has been shown to reduce disease severity and T lymphocyte migration into the s... |