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Project Number: | I01BX002773-01A1 |
| Title: | A Novel Drug Target for Aggressive Prostate Cancer |
| Principal Investigator: | Kerry Burnstein |
| Location: | Miami, FL |
| Congressional District Code: | 24 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2021 |
| FY 2021 Funding Amount: | $224,733 |
| Total Award Amount (all years): |
$1,046,213 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Metastatic castration resistant prostate cancer (mCRPC) commonly occurs in the skeleton and soft tissues and is hallmarked by enhanced expression of androgen receptor (AR) and constitutively active AR variants such as AR-V7. Transcriptome analyses of AR-V7 in CRPC cells identified increased expression of the vasoconstrictor and G protein-coupled receptor, arginine vasopressin receptor-1a (AVPR1a). Analysis of public human databases revealed significantly higher levels of AVPR1a mRNA in human spe... |