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Funded Project Details - FY2021

Project Number:

Title: Reprogrammed cell therapy for white matter restoration in aged brain ischemia
Principal Investigator:

Guodong Cao

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract Ischemia causes a massive loss of both oligodendrocytes and its progenitor cells (OPCs), the only cells responsible for myelination in the CNS, leading to axonal damage and demyelination, failure of nerve signal conduction, sensorimotor dysfunction, and cognitive impairments. Thus, OPC replacement therapy is a critical prerequisite for WM restoration and brain repair, especially for aged subjects who have more severe WMI and poor oligodendrocyte proliferative capacity compared to young...

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