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Project Number: | I01BX004197-01A1 |
| Title: | Early Diagnosis and Novel Treatment of Sepsis |
| Principal Investigator: | Frank J. Jacono |
| Location: | Cleveland, OH |
| Congressional District Code: | 11 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2022 |
| FY 2021 Funding Amount: | $154,750 |
| Total Award Amount (all years): |
$726,596 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Sepsis is a common and devastating syndrome induced by infection and results from an uncontrolled inflammatory response. As highlighted in the updated consensus definition for sepsis published this year (JAMA 23; 315:801), the initial inflammatory response to infection is beneficial; but this protective response can become dysregulated and harmful. The theoretical tipping-point at which inflammation transitions from defending to destroying homeostasis is not predictable, but it identifies the po... |