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Funded Project Details - FY2021

Project Number:

Title: Early Diagnosis and Novel Treatment of Sepsis
Principal Investigator:

Frank J. Jacono

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $154,750
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Sepsis is a common and devastating syndrome induced by infection and results from an uncontrolled inflammatory response. As highlighted in the updated consensus definition for sepsis published this year (JAMA 23; 315:801), the initial inflammatory response to infection is beneficial; but this protective response can become dysregulated and harmful. The theoretical tipping-point at which inflammation transitions from defending to destroying homeostasis is not predictable, but it identifies the po...

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