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Project Number: | I01BX004151-01 |
| Title: | Immunotargeting of reparative cells and theranostic nanosomes to cartilage lesions |
| Principal Investigator: | Karen A. Hasty |
| Location: | Memphis, TN |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - December 2021 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$798,510 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The ability to detect early cartilage damage in traumatic injury or degenerative arthritis has been limited, preventing treatment when therapies may be more beneficial. Depletion of proteoglycans/glycoproteins on the surface of the cartilage in these disorders results in unmasking of the underlying type II collagen (CII). This allows CII to serve as an immunologically recognizable target for monoclonal antibody to type II collagen (MabCII). MabCII can be fluorescently labeled for diagnosis of ca... |