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Funded Project Details - FY2021

Project Number:

Title: Catestatin improves glucose homeostasis and insulin sensitivity in diet-induced obese mice
Principal Investigator:

Sushil K. Mahata

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $389,812
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary. Obesity represents a state of chronic, low-grade tissue inflammation that contributes to insulin resistance (IR) steatosis and type 2 diabetes mellitus (T2DM). The demands for effective therapy call for improved understanding of the disease. There is a significant gap in our understanding of the endogenous factors that regulate both inflammatory responses and insulin sensitivity. In this application, we showed that a peptide, catestatin (CST), derived from a gene product, chromo...

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