Dysfunction of the membrane trafficking leads to ischemia-reperfusion brain injury
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Biomedical Laboratory R&D
January 2018 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Brain ischemia-reperfusion (IR) injury due to stroke and cardiac arrest is a leading cause of death and long-term disability, affecting thousands of Veterans every year. However, the molecular mechanisms underlying brain IR injury are still not completely understood. The objective of this proposal is to study a novel hypothesis that brain IR leads to a cascade of events resulting in inactivation of N-ethylmaleimide sensitive factor (NSF), massive buildup of damaged late endosomes (LEs), fatal re...