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Funded Project Details - FY2021

Project Number:

Title: Psychological stress reduces endocannabinoid tone: mechanisms and possible treatments
Principal Investigator:

Si-Qiong June Liu

Location: New Orleans, LA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $236,165
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


One debilitating mental health problem among veterans is post-traumatic stress disorder (PTSD), which is an anxiety disorder (PTSD) and develops following the experience of life- threatening psychological trauma. Individuals with PTSD have reduced circulating levels of endocannabinoids (eCB) including 2-AG. Since disruption of 2-AG signaling leads to mood disorders, impaired memory extinction and enhanced pain, the ability to reverse the stress- induced change in 2-AG production/degradation hold...

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