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Funded Project Details - FY2021

Project Number:

Title: The Interaction of parkin and environmental toxins in Parkinson’s disease
Principal Investigator:

Jian Feng

Location: Buffalo, NY
Congressional District Code: 26
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $207,516
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract Many environmental and genetic factors underlie the degeneration of nigral DA neurons in Parkinson's disease (PD). Exposure to pesticides such as rotenone and organochlorine herbicides such as 2,4-D, a major component of Agent Orange used in Vietnam War, has been linked to higher incidence of PD. Nigral DA neurons have massive axon arborization and are particularly vulnerable to microtubule-depolymerizing agents. Previous studies show that many environmental PD toxins impact on microtu...

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