Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX003831-01A1
Title: The Interaction of parkin and environmental toxins in Parkinson’s disease
Principal Investigator:

Jian Feng

Location: Buffalo, NY
Congressional District Code: 26
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $207,516
Total Award Amount
(all years):
$975,564
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Abstract Many environmental and genetic factors underlie the degeneration of nigral DA neurons in Parkinson's disease (PD). Exposure to pesticides such as rotenone and organochlorine herbicides such as 2,4-D, a major component of Agent Orange used in Vietnam War, has been linked to higher incidence of PD. Nigral DA neurons have massive axon arborization and are particularly vulnerable to microtubule-depolymerizing agents. Previous studies show that many environmental PD toxins impact on microtu...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.