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Project Number: | I01BX003831-01A1 |
| Title: | The Interaction of parkin and environmental toxins in Parkinsons disease |
| Principal Investigator: | Jian Feng |
| Location: | Buffalo, NY |
| Congressional District Code: | 26 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2022 |
| FY 2021 Funding Amount: | $207,516 |
| Total Award Amount (all years): |
$975,564 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Abstract Many environmental and genetic factors underlie the degeneration of nigral DA neurons in Parkinson's disease (PD). Exposure to pesticides such as rotenone and organochlorine herbicides such as 2,4-D, a major component of Agent Orange used in Vietnam War, has been linked to higher incidence of PD. Nigral DA neurons have massive axon arborization and are particularly vulnerable to microtubule-depolymerizing agents. Previous studies show that many environmental PD toxins impact on microtu... |