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Funded Project Details - FY2021




Project Number:

I01BX003440-01A2
Title: A novel estrogen modulator for the treatment of Alzheimer's disease
Principal Investigator:

Joseph F. Quinn

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$721,686
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

A number of studies have shown that the sex hormone, estrogen, has favorable or “neurotrophic” effects on neuronal cells in the brain. Unfortunately, clinical trials using estrogen revealed unacceptable side effects, including increased risk of blood clots and hormone- sensitive cancers. Moreover, estrogen is not practical for use in men, because it promotes unwanted physical changes and feminizing effects; consequently, estrogen has been abandoned as a treatment for AD. As an alterative strateg...



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