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Funded Project Details - FY2021

Project Number:

Title: Modulation of the Intestinal Microbiome in Obesity by a High Protein Diet
Principal Investigator:

Jonathan P Jacobs

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Clinical Science R&D
Project Period: July 2018 - June 2023
FY 2021 Funding Amount: $326,590
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


ABSTRACT A high protein diet has been shown in preclinical rodent models and clinical trials to be an effective obesity treatment that is associated with greater loss of body weight and fat mass and increased satiety compared to isocaloric standard protein diets. However, the mechanisms of this response have not been fully elucidated. I recently demonstrated in a rodent model that a high protein diet induces shifts in the intestinal microbiome including a bloom of Akkermansia muciniphila, a micr...

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