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Funded Project Details - FY2021




Project Number:

I01CX001668-01
Title: Reflux-Induced Oxidative DNA Damage Repair Early in Barrett's Carcinogenesis
Principal Investigator:

Kerry Dunbar

Location: Dallas, TX
Congressional District Code: 30
Research Service: Clinical Science R&D
Project Period: July 2018 - June 2023
FY 2021 Funding Amount: $22,396
Total Award Amount
(all years):
$666,250
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Project Summary Gastroesophageal reflux disease (GERD) can be complicated by Barrett’s esophagus, the condition in which a metaplastic, intestinal-type mucosa replaces esophageal squamous mucosa that has been damaged by GERD. Both GERD and Barrett’s esophagus are risk factors for esophageal adenocarcinoma, a deadly cancer whose incidence has been increasing rapidly for decades. Chronic GERD contributes to the malignant transformation of Barrett’s esophagus by causing inflammation, oxidative str...



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