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Funded Project Details - FY2021




Project Number:

I01RX002705-01A1
Title: Neuromodulation as a Therapy for PTSD following Chronic TBI
Principal Investigator:

John A Wolf

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: April 2018 - March 2023
FY 2021 Funding Amount: $272,369
Total Award Amount
(all years):
$1,099,568
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Although PTSD is a frequent co-morbidity of traumatic brain injury in Veterans, the neurophysiological basis underlying the contribution of TBI to PTSD remains unknown, and there are currently few effective treatments available for this prevalent co-morbidity. A number of human and rodent studies have demonstrated that TBI can exacerbate fear responses, and affect the ability to extinguish a conditioned fear response. Others have demonstrated in PTSD models that there is a shift in the balance b...



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