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Funded Project Details - FY2021

Project Number:

Title: Immune and Genetic Controls of Tissue Regeneration in Mice and Humans
Principal Investigator:

Thomas Leung

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: March 2018 - February 2023
FY 2021 Funding Amount: $175,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract/Summary Cutaneous wounds create significant health problems for Veterans, including wartime trauma, diabetic foot ulcers, pressure ulcers, and pathological scar formation. We aim to devise novel methods to stimulate self- repair mechanisms and to promote scar-less wound healing/full tissue regeneration in humans. We use a combination of loss-of-function mouse genetics, parabiosis (where the circulatory systems of two mice are surgically connected), mass cytometry, flow cytometry, genomi...

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