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Funded Project Details - FY2021

Project Number:

Title: Extracellular matrix-adipocyte metabolic crosstalk and diabetes
Principal Investigator:

Robert W. O' Rourke

Location: Ann Arbor, MI
Congressional District Code: 12
Research Service: Clinical Science R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $199,820
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


PROJECT SUMMARY ABSTRACT Obesity and associated metabolic disease, including type II diabetes, is a public health crisis, the risks of which are elevated in military Veterans. Adipose tissue metabolism is dysregulated in obesity and is a central mediator of diabetes pathogenesis, but underlying mechanisms are not well-defined. The extracellular matrix (ECM) is an understudied component of adipose tissue, and our preliminary data demonstrate that that ECM regulates adipocyte metabolic dysfunction...

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