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Funded Project Details - FY2021

Project Number:

Title: Role of Gut Microbial Translocation in Initiating Autoimmunity
Principal Investigator:

Gary S. Gilkeson

Location: Charleston, SC
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Genetic and environmental factors contribute to systemic lupus erythematosus (SLE). Previous studies showed environmental factors such as bacterial products or their-induced inflammatory mediators (e.g., IFN-α) are involved in SLE pathogenesis. Previous studies from others and we revealed that multiple autoAbs are more commonly detected in first-degree relatives of lupus patients (FDRs), compared to unrelated healthy controls (UHCs). In addition, FDRs have heightened levels of inflammation (e.g....

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