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Funded Project Details - FY2021




Project Number:

I01CX001631-01A2
Title: Pathogenesis and Treatment of AA Amyloidosis
Principal Investigator:

Merrill D. Benson

Location: Indianapolis, IN
Congressional District Code: 7
Research Service: Clinical Science R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
$741,250
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

AA (secondary, reactive) amyloidosis is a disease caused by extracellular deposition of insoluble β-pleated sheet fibrils composed of amyloid A (AA) protein, an N-terminal fragment of the acute phase protein serum amyloid A (SAA). The deposits disrupt tissue structure and eventually compromise organ function. Common sites of deposition include kidney, spleen, liver, and intestine. In humans proteinuria due to glomerular deposits is often the first clinical manifestation, and with increasing depo...



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