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Funded Project Details - FY2021




Project Number:

I01CX001038-05
Title: The neuropathology of mild traumatic brain injury in Alzheimer disease
Principal Investigator:

Thor D Stein

Location: Bedford, MA
Congressional District Code: 6
Research Service: Clinical Science R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $164,978
Total Award Amount
(all years):
$843,264
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Repetitive head impacts (RHI) lead to severe cognitive and behavioral symptoms and the progressive neurodegeneration of chronic traumatic encephalopathy (CTE). Trauma is also a known risk factor for Alzheimer disease (AD) and we hypothesize that a prolonged period of RHI can play a causative role in the development of AD as well as CTE. Currently, there are no disease modifying treatments for CTE or AD, and diagnosis of CTE can only be made at autopsy. Furthermore, little is known about the gene...



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