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Funded Project Details - FY2023

Project Number:

Title: The Functional Role of Exosomes in Stem Cell Mediated Cardiac Repair
Principal Investigator:

Jennifer K Lang

Location: Buffalo, NY
Congressional District Code: 26
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2024
FY 2023 Funding Amount: $281,927
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Recent studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium following myocardial infarction (MI). While paracrine signaling by CDC secreted exosomes (CDC-exo) is hypothesized to be the principal mediator of improved function, the contribution of exosomes secreted from grafted cells and their mechanisms of action have not been established. Our central hypothesis is that exosomes released by engrafted CDCs directly contribute to c...

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