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Funded Project Details - FY2021




Project Number:

I01BX004024-01A1
Title: Purinergic control of calcium flux in podocytes
Principal Investigator:

Alexander Staruschenko

Location: Milwaukee, WI
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $237,932
Total Award Amount
(all years):
$1,025,879
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The podocyte has become a crucial focus as a target for interventions in kidney disease due to its key role in regulating glomerular permeability and maintaining glomerular structure. Podocyte injury is believed to be pathogenetically and prognostically important in diabetic nephropathy (DN). One of the main factors determining pathological changes of glomerular morphology and permeability are linked to elevation of podocyte intracellular calcium ([Ca2+]i). Transient receptor potential canonical...



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