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Project Number: | I01BX004024-01A1 |
| Title: | Purinergic control of calcium flux in podocytes |
| Principal Investigator: | Alexander Staruschenko |
| Location: | Milwaukee, WI |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2023 |
| FY 2023 Funding Amount: | $209,988 |
| Total Award Amount (all years): |
$1,031,535 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The podocyte has become a crucial focus as a target for interventions in kidney disease due to its key role in regulating glomerular permeability and maintaining glomerular structure. Podocyte injury is believed to be pathogenetically and prognostically important in diabetic nephropathy (DN). One of the main factors determining pathological changes of glomerular morphology and permeability are linked to elevation of podocyte intracellular calcium ([Ca2+]i). Transient receptor potential canonical... |