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Funded Project Details - FY2021

Project Number:

Title: Cholesterol, Its Metabolites, and Nonalcoholic Steatohepatitis
Principal Investigator:

William M. Pandak

Location: Richmond, VA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $156,767
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The metabolic pathways in nonalcoholic steatohepatitis (NASH) that contribute to fatty liver’s progression to inflammation are being intensely studied. One pathway which has been overlooked is the CYP27A1 initiated ‘alternative pathway.’ This pathway is responsible for the metabolism of cholesterol to intracellular regulatory oxysterols. The pathway’s subsequent 7α- hydroxylation of these oxysterols and their lipotoxic metabolites by CYP7B1 is what is believed to eliminate their regulatory effec...

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