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Funded Project Details - FY2021

Project Number:

Title: Role of claudin-1 in Colon Cancer
Principal Investigator:

Punita Dhawan

Location: Omaha, NE
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $260,910
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The colon cancer (CRC) staging, at the time of disease diagnosis, is critical for patient survival, which ranges from 90% for patients with localized disease to meagre 13% for the ones with metastasis. Thus, improved understanding of the molecular regulation of CRC-progression and metastasis is critical and urgent, to develop novel therapies. In this regard, studies from our, and other laboratories, have provided strong support for a casual role for upregulated claudin- 1 expression in promoting...

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