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Funded Project Details - FY2021




Project Number:

I01BX003275-01A2
Title: Innate Pattern Recognition Receptor and Acetaminophen-induced Liver Injury
Principal Investigator:

Xiang-Yang Wang

Location: Richmond, VA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $251,884
Total Award Amount
(all years):
$1,247,274
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Hepatotoxicity induced by acetaminophen (APAP) has become the leading cause of acute liver failure among the general and the VA populations. The APAP overdose or abuse causing severe liver injury remains a great threat to veterans. Currently, the standard of care implemented uses high doses of the L-cysteine precursor N-Acetylcysteine (NAC) making it the only treatment option for patients that suffer from APAP-induced liver injury (AILI). Unfortunately, the therapeutic window of NAC administrati...



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