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Project Number: | I01BX003275-01A2 |
| Title: | Innate Pattern Recognition Receptor and Acetaminophen-induced Liver Injury |
| Principal Investigator: | Xiang-Yang Wang |
| Location: | Richmond, VA |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2019 - December 2022 |
| FY 2021 Funding Amount: | $251,884 |
| Total Award Amount (all years): |
$1,247,274 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Hepatotoxicity induced by acetaminophen (APAP) has become the leading cause of acute liver failure among the general and the VA populations. The APAP overdose or abuse causing severe liver injury remains a great threat to veterans. Currently, the standard of care implemented uses high doses of the L-cysteine precursor N-Acetylcysteine (NAC) making it the only treatment option for patients that suffer from APAP-induced liver injury (AILI). Unfortunately, the therapeutic window of NAC administrati... |