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Project Number: | I01BX002108-05A1 |
| Title: | Dysregulation of the inflammatory response by Francisella tularensis |
| Principal Investigator: | Lee-Ann H. Allen |
| Location: | Columbia, MO |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2023 |
| FY 2021 Funding Amount: | $95,986 |
| Total Award Amount (all years): |
$1,052,911 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Tularemia is a potentially fatal disease and the causative agent, Francisella tularensis (Ft), is one of few bacterial pathogens that can infect both neutrophils (polymorphonuclear leukocytes, PMNs) and macrophages. Notably, macrophages and neutrophils appear to play distinctly different roles in tularemia pathogenesis, with macrophages acting as major vehicles for bacterial growth and dissemination, and PMNs playing a central role in host tissue destruction. Neutrophils are short lived, and unl... |