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Funded Project Details - FY2021

Project Number:

Title: Molecular basis for mechanosensitivity of esophageal enteric neurons (EMN)
Principal Investigator:

Ravinder K. Mittal

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Introduction: Impaired lower esophageal sphincter (LES) relaxation is the hallmark of achalasia esophagus and spastic motor disorders of the esophagus. On the other hand, excessive LES relaxation (transient LES relaxation) leads to reflux disease. Therefore, LES dysfunction contributes to significant morbidity and health related costs. Our current understanding is that the LES relaxation is neurogenic, mediated by vagus nerve which synapses with the inhibitory motor neurons of the myenteric plex...

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