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Funded Project Details - FY2021

Project Number:

Title: Cell Specific Mineralocorticoid Signaling, Insulin Resistance and Cardiovascular Stiffness
Principal Investigator:

Guido Lastra

Location: Columbia, MO
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


In my last funded VA merit I proposed to investigate novel molecular mechanisms by which angiotensin II (Ang II), aldosterone and a WD (high in saturated fat and refined carbohydrates individually and collectively promotes insulin (INS) resistance in cardiovascular (CV) and skeletal muscle tissue in male rodents. Because of the increasing awareness by the NIH, the VA, the American Diabetes Association and American Heart Association regarding incorporation of females in research, we performed com...

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