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Funded Project Details - FY2021




Project Number:

I01BX003801-01A2
Title: Identification of the growth-promoting PKD/YAP axis as a novel target for the statins in intestinal epithelial cells.
Principal Investigator:

Enrique J. Rozengurt

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $235,112
Total Award Amount
(all years):
$1,019,354
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The sequential proliferation, lineage-specific differentiation, migration and death of the epithelial cells of the intestinal mucosa is a tightly regulated process modulated by a broad range of regulatory peptides, neurotransmitters, bioactive lipids and differentiation signals. Many of these stimuli act through heptahelical G protein-coupled receptors (GPCRs). Despite their fundamental importance, the intracellular signal transduction mechanisms involved remain incompletely understood. Protein...



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