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Funded Project Details - FY2021

Project Number:

Title: How Does a Young Extracellular Matrix Rejuvenate Old Mesenchymal Stem Cells?
Principal Investigator:

Xiao-Dong Chen

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $259,547
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Previously, we reported that deficits in self-renewal and bone formation capacity in bone marrow-derived mesenchymal stem cells (BM-MSCs) from elderly could be completely restored by culture on extracellular matrix (ECM) synthesized by BM stromal cells from young donors (young-ECM). However, this restorative effect was substantially diminished when cells from young or old donors were cultured on ECM synthesized by BM stromal cells from old donors (old-ECM). The goal of this renewal application i...

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