Funded Project Details - FY2021
|Title:|| How Does a Young Extracellular Matrix Rejuvenate Old Mesenchymal Stem Cells?|
||San Antonio, TX
|Congressional District Code:
||Biomedical Laboratory R&D
|| July 2018 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Previously, we reported that deficits in self-renewal and bone formation capacity in bone marrow-derived mesenchymal stem cells (BM-MSCs) from elderly could be completely restored by culture on extracellular matrix (ECM) synthesized by BM stromal cells from young donors (young-ECM). However, this restorative effect was substantially diminished when cells from young or old donors were cultured on ECM synthesized by BM stromal cells from old donors (old-ECM). The goal of this renewal application i...
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