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Funded Project Details - FY2021

Project Number:

Title: Decreased CNS leptin activity in co-morbid depression and obesity
Principal Investigator:

Lawrence P Reagan

Location: Columbia, SC
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $264,908
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The overarching goal of this proposal is to demonstrate obesity-induced neuroinflammation in the raphe nucleus decreases serotonin synthesis which decreases hippocampal serotonin levels, thereby providing a neurochemical mechanism for co-morbid depressive illness in obesity. The incidence of obesity is greater in the VA population when compared with the general adult US population, with current estimates suggesting that over 80% of Veterans may be classified as obese or overweight. The complica...

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