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Funded Project Details - FY2021

Project Number:

Title: Epithelial Beta-catenin Signaling Improves Chronic Renal Injury
Principal Investigator:

Leslie Gewin

Location: Nashville, TN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Chronic kidney disease (CKD) is a growing public health problem that affects more than 10% of Veterans, increases morbidity and mortality, and imposes a huge economic burden. Persistent renal tubular injury is an important component of tubulointerstitial fibrosis (TIF), the common feature of progressive CKD of any etiology. Growth factors such as transforming growth factor- (TGF-) and Wnt/-catenin are important determinants of how tubular epithelia respond to injury. Various inhibitors of the...

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