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Funded Project Details - FY2021

Project Number:

Title: Targeting Macrophage Lysosome Biogenesis Program in Cardiomyopathy and Heart Failure
Principal Investigator:

Abhivav Diwan

Location: St Louis, MO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Heart failure due to myocardial infarction (MI) is leading cause of death in the United States. Infiltration of peripheral monocytes and resident cardiac macrophages are postulated to play a dual role in the post-MI period, characterized by pro-inflammatory signaling and phagocytic removal of dead cells in the early phase and a shift towards anti-inflammatory signaling to promote reparative phase. Persistence of pro-inflammatory macrophages correlates with maladaptive left ventricular remodeling...

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