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Funded Project Details - FY2021




Project Number:

I01BX003803-01A1
Title: Autophagy in Polycystic Kidney Disease (PKD)
Principal Investigator:

Charles L. Edelstein

Location: Denver, CO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $156,760
Total Award Amount
(all years):
$706,090
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Autophagy is a process that takes place in all eukaryotic cells that keeps cells alive under stressful conditions. In autophagy there is the sequestration of damaged organelles into double-membraned autophagosomes that subsequently fuse with lysosomes where their cargoes are delivered for degradation and recycling. In the healthy kidney, autophagy plays an important role in the homeostasis and viability of renal tubular epithelial cells. There is indirect evidence that PKD is a case of suppresse...



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