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Funded Project Details - FY2021

Project Number:

Title: Mechanisms of imbalanced inward and outward arteriovenous fistula remodeling
Principal Investigator:

Yan-Ting E Shiu

Location: Salt Lake City, UT
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $234,569
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The inability of arteriovenous fistulas (AVFs) to mature sufficiently for adequate dialysis is a major clinical problem confronting chronic hemodialysis. Up to 60% of newly created AVFs fail to mature, and currently there is no effective strategy to enhance AVF maturation. AVF maturation failure results from an imbalance between inward remodeling due to venous neointimal hyperplasia and outward remodeling due to sustained venous dilation. Although inward remodeling has been intensively studied,...

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