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Funded Project Details - FY2021

Project Number:

Title: HCV and co-morbid alcohol use disorders: a translational investigation of antiviral therapy outcomes on CNS function
Principal Investigator:

Jennifer Loftis

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $315,133
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Chronic hepatitis C virus (HCV) infection is often associated with extrahepatic manifestations, including central nervous system (CNS) damage and neuropsychiatric impairments that can be exacerbated by alcohol abuse. More than half of patients with chronic HCV infection complain of “brain fog” (impaired cognition, fatigue). The introduction of direct-acting antiviral (DAA) therapies has revolutionized HCV treatment, with sustained viral response (SVR) rates of ~90%. The VA is now offering DAA th...

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