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Funded Project Details - FY2021

Project Number:

Title: Dynamics of the brain epigenome with aging
Principal Investigator:

Willard M Freeman

Location: Oklahoma City, OK
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $254,646
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Regulation of brain aging through epigenetic processes is currently one of the most provocative areas of aging research. Epigenetic processes in the central nervous system may play a mechanistic role in susceptibility to and progression of cognitive decline and age-related neurodegenerative disease such as Alzheimer’s disease and other dementias. DNA modifications, principally methylation and hydroxymethylation of cytosines (mC and hmC respectively), are fundamental regulators of DNA accessibili...

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