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Funded Project Details - FY2021




Project Number:

I01BX003906-01A2
Title: Dynamics of the brain epigenome with aging
Principal Investigator:

Willard M Freeman

Location: Oklahoma City, OK
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $254,646
Total Award Amount
(all years):
$1,248,251
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Regulation of brain aging through epigenetic processes is currently one of the most provocative areas of aging research. Epigenetic processes in the central nervous system may play a mechanistic role in susceptibility to and progression of cognitive decline and age-related neurodegenerative disease such as Alzheimer’s disease and other dementias. DNA modifications, principally methylation and hydroxymethylation of cytosines (mC and hmC respectively), are fundamental regulators of DNA accessibili...



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