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Funded Project Details - FY2021

Project Number:

Title: Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma
Principal Investigator:

Mark W Logue

Location: Boston, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - June 2022
FY 2021 Funding Amount: $51,318
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Late-onset Alzheimer’s disease (AD) is the most common form of age-related dementia. PTSD and dementia co-occur more often than expected by chance. One potential reason for this comorbidity is that AD genes may influence the risk for both AD and PTSD. APOE, the strongest AD genetic risk factor, has also been implicated as a risk factor for combat-related PTSD. The initial effects of these genes may be apparent in middle age, ahead of the usual age of AD onset. Our recent MRI study found that an...

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