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Funded Project Details - FY2021

Project Number:

Title: Assessing the role of metabolism in monocyte to macrophage differentiation in pulmonary fibrosis
Principal Investigator:

G. R.Scott Budinger

Location: Chicago, IL
Congressional District Code: 7
Research Service: Clinical Science R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary Idiopathic Pulmonary Fibrosis (IPF) has a prognosis worse than most cancers, with only 20-30 percent of patients surviving 5 years after diagnosis. The pathophysiology in IPF relates to dysregulated repair after injury to the alveolo-capillary though the mechanisms that link alveolar capillary membrane injury with fibroblast activation and disordered repair are incompletely understood. In a recent publication we provide clear genetic evidence that alveolar macrophages are key eff...

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