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Funded Project Details - FY2021

Project Number:

Title: Impact of Comorbidities on Stroke Outcomes and Treatments
Principal Investigator:

Stephen Tomlinson

Location: Charleston, SC
Congressional District Code: 1
Research Service: Rehabilitation R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $233,350
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The complement system has an important role in the pathogenesis of inflammatory injury and subsequent recovery following ischemic stroke. In the previous award, we identified complement-dependent mechanisms of post-stroke injury and recovery, and we characterized a set of complement inhibitors that are targeted to neoepitopes expressed in the injured brain following stroke. We also determined that complement inhibition significantly improved the outcomes of rehabilitative therapy and thrombolyti...

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