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Project Number: | I01RX001141-05A1 |
| Title: | Impact of Comorbidities on Stroke Outcomes and Treatments |
| Principal Investigator: | Stephen Tomlinson |
| Location: | Charleston, SC |
| Congressional District Code: | 1 |
| Research Service: | Rehabilitation R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $233,350 |
| Total Award Amount (all years): |
$961,050 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The complement system has an important role in the pathogenesis of inflammatory injury and subsequent recovery following ischemic stroke. In the previous award, we identified complement-dependent mechanisms of post-stroke injury and recovery, and we characterized a set of complement inhibitors that are targeted to neoepitopes expressed in the injured brain following stroke. We also determined that complement inhibition significantly improved the outcomes of rehabilitative therapy and thrombolyti... |