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Funded Project Details - FY2021




Project Number:

I01RX002798-01A1
Title: Novel Regenerative Therapeutic in Chronic Complex TBI
Principal Investigator:

Christine E. Marx

Location: Durham, NC
Congressional District Code: 1
Research Service: Rehabilitation R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $267,439
Total Award Amount
(all years):
$1,099,967
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Novel Regenerative Therapeutic in Chronic Complex TBI Allopregnanolone (ALLO) is a neurosteroid endogenously produced in brain that exhibits pleiotropic actions highly relevant to the neurobiology and treatment of chronic complex TBI. ALLO exhibits pronounced regenerative actions, in addition to marked neuroprotective, analgesic, and anti-inflammatory effects in rodent models. Furthermore, our recent human data suggest that ALLO is decreased in TBI, suggesting that ameliorating deficits of this...



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