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Funded Project Details - FY2021




Project Number:

IK2RX002781-01A1
Title: Mechanisms and treatments of mitochondrial dysfunction in paralyzed skeletal muscle after spinal cord injury
Principal Investigator:

Zachary A Graham

Location: Birmingham, AL
Congressional District Code: 13
Research Service: Rehabilitation R&D
Project Period: October 2018 - September 2023
FY 2021 Funding Amount: $206,797
Total Award Amount
(all years):
$986,361
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Unloading and paralysis of skeletal muscle after spinal cord injury (SCI) results in severe loss of muscle contractile function and deleterious alterations in mitochondrial morphology and performance. One potential mechanism is the de novo appearance of connexin hemichannels (Cx) in paralyzed muscle. We hypothesize Cx destabilize mitochondrial function in paralyzed muscle. Cx43 and 45 appear in the sarcolemma de novo after paralysis and are believed to contribute to muscle atrophy by permitting...



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