Funded Project Details - FY2021
|Title:|| Mechanisms and treatments of mitochondrial dysfunction in paralyzed skeletal muscle after spinal cord injury|
Zachary A Graham
|Congressional District Code:
|| October 2018 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Unloading and paralysis of skeletal muscle after spinal cord injury (SCI) results in severe loss of muscle contractile function and deleterious alterations in mitochondrial morphology and performance. One potential mechanism is the de novo appearance of connexin hemichannels (Cx) in paralyzed muscle. We hypothesize Cx destabilize mitochondrial function in paralyzed muscle. Cx43 and 45 appear in the sarcolemma de novo after paralysis and are believed to contribute to muscle atrophy by permitting...
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