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Project Number: | I01BX004299-01A1 |
| Title: | PGI2 inhibition of pulmonary innate allergic immune responses |
| Principal Investigator: | Ray S Peebles |
| Location: | Nashville, TN |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $156,702 |
| Total Award Amount (all years): |
$701,408 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Allergic airway inflammation is a hallmark of asthma, one of the most common chronic diseases in the United States. The group 2 innate lymphoid cell (ILC2) is a recently described cell type that is a far more potent producer of IL-5 and IL-13 on a per cell basis than CD4+ Th2 cells, and there is increasing evidence that ILC2 are critical to the genesis and amplification of allergic inflammatory responses. In the last funding cycle of this VA Merit Award, we reported that prostaglandin (PG) I2 ne... |